Spurs are missing yet another defender due to injury with full-back Destiny Udogie set to miss six weeks of action.
Djed Spence makes a timely return from suspension while midfielder Rodrigo Bentancur is banned once more after collecting a fifth yellow card of the season last weekend.
Newcastle are without the suspended Fabian Schar but fellow defender Sven Botman could return to the squad for the first time since March.
Head coach Eddie Howe has reported no fresh injury concerns meaning Kieran Trippier should be fit to face his former club.
Emil Krafth, Jamaal Lascelles, Nick Pope and Callum Wilson all remain absent.
Tottenham have won two of their previous three top-flight home clashes with Newcastle, losing the other.
However, the Magpies have beaten Spurs in four of their last five Premier League meetings, suffering just one defeat.
Starting XI prediction
Forster
Porro – Dragusin – Gray – Reguilon
Sarr – Bissouma
Kulusevski
Johnson – Solanke – Son